Structure and Source

Mevalonate (C?H??O?), whose full name is 3,5-dihydroxy-3-methylvalerate, is a precursor compound of the mevalonate pathway and an important intermediate in the biosynthesis of cholesterol and numerous terpenoids. Its 3-position carbon has chirality, but only the 3R isomer can be utilized by organisms. Mevalonic acid is an oily substance that is easily soluble in water, leading to lactone formation and the production of mevalonolactone. It was first discovered in sake and can be synthesized by the human body, but its synthesis ability decreases with age.

Biological Activity

The mevalonate pathway is an important and complex signaling pathway used to produce various isoprenoid substances, such as cholesterol, vitamin D, lipoproteins, polyols, ubiquinones, etc. Mevalonic acid forms farnesyl pyrophosphate through the mevalonate pathway, which is then converted into squalene through the cholesterol biosynthesis pathway, and then into cholesterol. Mevalonic acid itself has antioxidant function, which counteracts ultraviolet rays and enhances cell vitality. Mevalonolactone has a small molecular weight and is easily absorbed by cells through the membrane. It also has the effect of promoting the synthesis of collagen in the human body, and is known as a skincare wonder. It is also called the “fairy water” in the cosmetics industry.